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In contrast, AAV vectors, especially self-complementary AAV2 (scAAV2), have demonstrated superior penetration and stable gene expression in intact joint tissues
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J Mater Chem B 9:38743884
Gastrointestinal dysfunction is an early and common feature of PD up to 80% of PD patients experience chronic constipation and other GI issues, often years before motor symptoms [147]
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